Endocrine Abstracts

Seventy percent of women bearing PCOS are obese; adiponectin and TNFα, as obesity markers, have a dual role in the sensitivity and action of insulin. Adiponectin (insulin sensitising) decreases, whereas, TNFα, IL6 (negative regulators of insulin pathway) increases in obese-women. Moreover, TNFα decreases the transcript and protein levels of adiponectin. These changes could affect the normal energetic status in endometrium, tissue that exhibits abnormal insulin s...

The importance of cell cycle regulation in pituitary biology has been suggested from the fact that many gene-targeted mouse models of cell cycle mutations develop diverse pituitary pathologies. The retinoblastoma protein (pRb)/cyclin-dependent kinase 4 (Cdk4) pathway, one of the major mitogen-sensor routes in the cell, seems to be critical in the control of pituitary cell proliferation. Both inactivation of pRb or hyperactivation of Cdk4 result in pituitary hyperplasias or tum...

Introduction: Gestational diabetes (GD) is frequently associated with obesity and family history of diabetes. Besides these, other risks factors have been proposed, as previous GD, macrosomy or abnormal reproductive history.Methods: We conducted a retrospective comparative study including all patients diagnosed of GD during 1999 and 2008. The analyzed variables were incidence and risk factors of GD.Results: We included 384 patients...

Pancreatic neuroendocrine tumors (PanNETs) are heterogeneous neoplasms with a relatively low but increasing incidence, mainly due to the difficulty in diagnosing this disease in its early stages. This notably complicates the treatment of this pathology and leads to a poor prognosis. One of the main reasons for this problem is the lack of adequate diagnostic biomarkers as well as effective therapeutic targets. In this sense, there is still a limited knowledge about alternative ...